receptors – Communicable Diseases Research

An experimental test of the nicotinic hypothesis of COVID-19

Article

Published on 2022-11-012022-11-16
Journal: Proceedings of the National Academy of Sciences of
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

SARS-CoV-2 cell entry beyond the ACE2 receptor

Article

Published on 2022-11-012022-11-16
Journal: Molecular biology reports
[Category] COVID19(2023년), SARS, 변종,

De novo selected hACE2 mimics that integrate hotspot peptides with aptameric scaffolds for binding tolerance of SARS-CoV-2 variants

Article

Published on 2022-10-282022-11-15
Journal: Science Advances
[Category] COVID19(2023년), SARS, 변종, 치료제,

The pH Robustness of Bacterial Sensing

Article

Published on 2022-10-262022-11-16
Journal: mBio
[Category] 유전자 메커니즘,

[키워드] analyzed appear Bacteria Bacterial bacterial adaptation binding can be used change chaperone chemoreceptor chemotaxis condition conditions COVID-19 pandemic cytosolic demonstrated demonstration determine dimeric domain eight energy Escherichia coli extreme facilitate form Hormones in vivo include information intrinsic isothermal titration calorimetry Ligand ligands mechanism MONITOR Neurotransmitters nine pathway periplasmic pH pH robustness pH value progression Protein Proteins Pseudomonas aeruginosa quorum-sensing receptors recognize reported Research resonance respond response reveal robustness sensing sensor domains signal Signal transduction signal transduction. Signaling TAR tested ultracentrifugation was obtained
[DOI] 10.1128/mbio.01650-22 PMC 바로가기

Systems Bioinformatics Reveals Possible Relationship between COVID-19 and the Development of Neurological Diseases and Neuropsychiatric Disorders

Article

Published on 2022-10-162022-11-16
Journal: Viruses
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Acidic acute respiratory syndrome Analysis app Autoimmunity bioinformatics biological processe Combination contribute coronavirus COVID-19 development disease disease-associated disorder disorders dysregulation epitope Epitopes genetic risk factor GFAp Host identify incidence include increased risk indicated Infection linear MAPT microtubule-associated protein modulated molecular molecular mimicry motif Multiple Myasthenia network biology neurodegenerative Neurodegenerative diseases neurological Neurological disease Neurological diseases Neurological disorder Neuropsychiatric neuropsychiatric disorders PPI precursor Protein protein-protein interaction Proteins receptors recognize relationship SARS-CoV-2 SARS-CoV-2 epitope SARS-COV-2 infection sclerosis sequence similarity System systems bioinformatics.
[DOI] 10.3390/v14102270 PMC 바로가기

The TLR-NF-kB axis contributes to the monocytic inflammatory response against a virulent strain of Lichtheimia corymbifera, a causative agent of invasive mucormycosis

Article

Published on 2022-10-132022-11-15
Journal: Frontiers in Immunology
[Category] 진단,

[키워드] 24 hours activated Activation Apoptosis apoptotic cascade caused Cell cell damage characterized contribute COVID-19 CTLs Cytokines Diabetes Mellitus Diagnosis Diseases ENhance exhibit fungal Fungal infection fungi Hematological malignancies host cell Host immune response host inflammatory response host-pathogen interactions human monocyte human monocytes IL-1β IL-6 increase in individual Infection Inflammatory Inflammatory response inflammatory signaling Interaction invasive killing life-threatening modulation monocyte mortality rate Mucorales Mucormycosis NF-kB Occurrence organ pathogenic phagocyte phagocytosis priming pro-inflammatory cytokine produced progression PRRs receptor receptors receptors. regulate secreted signaling pathway spore susceptible synergistic therapy TLR TLR4 TLRs TNF-α Toll-like receptor transcription factor virulent
[DOI] 10.3389/fimmu.2022.882921 PMC 바로가기

Omicron (BA.1) and sub-variants (BA.1.1, BA.2, and BA.3) of SARS-CoV-2 spike infectivity and pathogenicity: A comparative sequence and structural-based computational assessment

SARS-CoV-2 스파이크 감염성 및 병원성의 오미크론(BA.1) 및 하위 변이체(BA.1.1, BA.2 및 BA.3): 비교 시퀀스 및 구조 기반 계산 평가

Article

Published on 2022-10-012022-09-11
Journal: Journal of medical virology
[Category] COVID19(2023년), SARS, 변종,

[키워드] ACE2 binding acute respiratory syndrome acute respiratory syndrome coronavirus acute respiratory syndrome coronavirus 2 Analysis angiotensin BA.1 BA.2 BA.3 BA1.1 bind binding affinity bronchial cells computational tool computational tools contribute contributing to coronavirus COVID-19 Deleterious domain Effectiveness electrostatic expressed Factor hACE2 higher affinity human ACE2 human Angiotensin-converting enzyme Human angiotensin-converting enzyme 2 hydrogen hydrogen bonds indicate Interaction K417N less lineages Lower respiratory tract lung mutated Mutation mutations N-terminal domain N501Y negative NTD omicron Omicron variant pathogenicity positive predicted Q498 RBD RBM receptor receptors residue residues Salt Bridge SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2. sequence severe acute respiratory syndrome Coronavirus significantly Spike protein Spread surface potential T478K the RBD the spike protein thought Transmission transmission potential variant variants wild-type
[DOI] 10.1002/jmv.27927 PMC 바로가기 [Article Type] Article

Molecular mechanisms involved in anosmia induced by SARS-CoV-2, with a focus on the transmembrane serine protease TMPRSS2

막횡단 세린 프로테아제 TMPRSS2를 중심으로 SARS-CoV-2에 의해 유도된 후각장애와 관련된 분자 기전

Review

Published on 2022-10-012022-09-11
Journal: Archives of Virology
[Category] COVID19(2023년), SARS, 유전자 메커니즘,

[키워드] Anosmia Apoptosis blockade camostat caused cell entry cellular and molecular chromosome chromosome 21 cleaving Delta dependent on disease disorder dysfunction entry of SARS-CoV-2 event ExoN exons facilitate functional gene encoding Genetic variations help host cell Inflammation involved mechanism nafamostat neuronal number of symptoms olfactory dysfunction olfactory neuroepithelium omicron overcome pandemic virus receptor receptors risk SARS-CoV-2 Serine serine protease serine protease inhibitor serine protease inhibitors shown strain Strains Symptoms therapeutic TMPRSS2 transmembrane serine protease viral S protein virus
[DOI] 10.1007/s00705-022-05545-0 PMC 바로가기 [Article Type] Review

The deglycosylated form of 1E12 inhibits platelet activation and prothrombotic effects induced by VITT antibodies

Article

Published on 2022-10-012022-11-15
Journal: Haematologica
[Category] 진단,

Dysregulated autoantibodies targeting vaso- and immunoregulatory receptors in Post COVID Syndrome correlate with symptom severity

Article

Published on 2022-09-272022-11-15
Journal: Frontiers in Immunology
[Category] 진단,

[키워드] accompanied ADRA2A ADRB2 alteration analyzed Asymptomatic autoantibodies autoantibody autonomic Autonomic nervous system autonomous chronic chronic fatigue syndrome classification Classifier Control control group control groups correlated correlation COVID COVID-19 Diagnostic Criteria disease dysregulation Evidence exploratory study fatigue G-protein G-protein coupled receptor groups immunoregulation indicated involved ME/CFS, Mild-to-moderate MOST nervous system organ dysfunction outcomes Pathogenesis Patient patients plethora Post COVID syndrome random receptor receptors Regulatory renin-angiotensin system renin-angiotensin system. seronegative serum severity STAB1 subset Symptom symptom severity syndrome
[DOI] 10.3389/fimmu.2022.981532 PMC 바로가기